In the first part of the reaction, the biotin cofactor is carboxylated using bicarbonate as a substrate with ATP to drive the formation of a "high energy" bond with respect to its hydrolysis product intermediate. Each subunit contains a biotin carboxylase (BC) domain shown in blue, a carboxytransferase (CT) domain shown in yellow, and the biotin-carboxyl carrier protein (BCCP) domain shown in red and green.įigure modified from Liu, Y., et al (2018) Nat Commun 9:1384 (a) shows the space-filling model while (b) shows the major domains as a cartoon graphic. The structure of glucose can be represented in one of the following ways: 1. Two subunits are shown in color, with the other two indicated in gray at the back of the structure.
The overall structure of the Pyruvate Carboxylase is a tetramer that contains four functional protein subunits. \) Structure of the Pyruvate Carboxylase Enzyme.
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